Evaluation of ETV6/RUNX1 Fusion and Additional Abnormalities Involving ETV6 and/or RUNX1 Genes Using FISH Technique in Patients with Childhood Acute Lymphoblastic Leukemia.

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dc.contributor.author Aydin, Cigdem
dc.contributor.author Manguoglu, Ayse Esra
dc.contributor.author Tayfun, Funda
dc.contributor.author Kupesiz, Alphan
dc.contributor.author Akkaya, Bahar
dc.contributor.author Çetin, Zafer
dc.contributor.author Clark, Ozden Altiok
dc.contributor.author Karauzum, Sibel Berker
dc.date.accessioned 2021-06-17T07:32:10Z
dc.date.available 2021-06-17T07:32:10Z
dc.date.issued 2016
dc.identifier.issn 0967-3849
dc.identifier.other 27065576
dc.identifier.uri https://doi.org/ 10.1007/s12288-015-0557-7 en_US
dc.identifier.uri http://openaccess.sanko.edu.tr/xmlui/handle/20.500.12527/216
dc.description.abstract Childhood acute lymphoblastic leukemia (ALL) is the most common type of childhood leukemia. Specifically, ALL is a malignant disorder of the lymphoid progenitor cells, with a peak incidence among children aged 2-5 years. The t(12;21)(p13;q22) translocation occurs in 25 % of childhood B cell precursor ALL. In this study, bone marrow samples were obtained from 165 patients with childhood ALL. We analyzed the t(12;21) translocation and other related abnormalities using the fluorescent in situ hybridization (FISH) technique with the ETV6(TEL)/RUNX1(AML1) ES dual color translocation probe. Conventional cytogenetic analyses were also performed. ETV6 and RUNX1 related chromosomal abnormalities were found in 42 (25.5 %) of the 165 patients with childhood ALL. Among these 42 patients, structural changes were detected in 33 (78.6 %) and numerical abnormalities in 9 (21.4 %). The frequency of FISH abnormalities in pediatric ALL cases were as follows: 8.5 % for t(12;21)(p13;q22) ETV6/RUNX1 fusion, 6.0 % for RUNX1 amplification, 3.0 % for tetrasomy/trisomy 21, 1.8 % for ETV6 deletion, 1.21 % for ETV6 deletion with RUNX1 amplification, 1.21 % for ETV6 amplification with RUNX1 amplification, 0.6 % for polyploidy, 0.6 % for RUNX1 deletion, and 0.6 % for diminished ETV6 signal. The most common structural abnormality was the t(12;21) translocation, followed by RUNX1 amplification and ETV6 deletion, while the most commonly observed numerical abnormality was trisomy 21. en_US
dc.language.iso English en_US
dc.publisher SPRINGER, VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Acute lymphoblastic leukemia en_US
dc.subject ETV6 en_US
dc.subject FISH en_US
dc.subject RUNX1 en_US
dc.subject t(12;21) translocation en_US
dc.title Evaluation of ETV6/RUNX1 Fusion and Additional Abnormalities Involving ETV6 and/or RUNX1 Genes Using FISH Technique in Patients with Childhood Acute Lymphoblastic Leukemia. en_US
dc.type Other en_US
dc.relation.journal CHROMOSOME RESEARCH en_US
dc.identifier.startpage 90 en_US
dc.identifier.endpage 91 en_US
dc.identifier.volume 23 en_US
dc.contributor.authorID 0000-0003-0125-235X : Zafer Çetin en_US
dc.identifier.wos 000411861000156 en_US
dc.identifier.doi 10.1007/s12288-015-0557-7 en_US
dc.contributor.sankoauthor Zafer Çetin en_US


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Gazimuhtar Paşa Bulvarı
No:36
27090
Şehitkamil / GAZİANTEP