Differentiating cancerous tissues from noncancerous tissues using single-fiber reflectance spectroscopy with different fiber diameters.

Show simple item record

dc.contributor.author Sircan-Kuçuksayan, Aslinur
dc.contributor.author Denkceken, Tuba
dc.contributor.author Canpolat, Murat
dc.date.accessioned 2021-06-22T11:43:30Z
dc.date.available 2021-06-22T11:43:30Z
dc.date.issued 2015
dc.identifier.issn 1083-3668
dc.identifier.other 26590218
dc.identifier.uri https://doi.org/ 10.1117/1.JBO.20.11.115007 en_US
dc.identifier.uri http://openaccess.sanko.edu.tr/xmlui/handle/20.500.12527/235
dc.description.abstract Elastic light-scattering spectra acquired with single-fiber optical probes with diameters of 100, 200, 400, 600, 800, 1000, 1200, and 1500 μm were used to differentiate cancerous from noncancerous prostate tissues. The spectra were acquired ex vivo on 24 excised prostate tissue samples collected from four patients. For each probe, the spectra and histopathology results were compared in order to investigate the correlation between the core diameters of the single-fiber optical probe and successful differentiation between cancerous and noncancerous prostate tissues. The spectra acquired using probes with a fiber core diameter of 400 μm or smaller successfully differentiated cancerous from noncancerous prostate tissues. Next, the spectra were acquired from monosized polystyrene microspheres with a diameter of 5.00±0.01 μm to investigate the correlation between the core diameters of the probes and the Mie oscillations on the spectra. Monte Carlo simulations of the light distribution of the tissue phantoms were run to interrogate whether the light detected by the probes with different fiber core diameters was in the ballistic or diffusive regime. If the single-fiber optical probes detect light in the ballistic regime, the spectra can be used to differentiate between cancerous and noncancerous tissues. en_US
dc.language.iso English en_US
dc.publisher SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS, 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject single fiber en_US
dc.subject cancerous tissue en_US
dc.subject light scattering en_US
dc.subject polystyrene en_US
dc.subject reflectance; en_US
dc.subject spectroscopy en_US
dc.title Differentiating cancerous tissues from noncancerous tissues using single-fiber reflectance spectroscopy with different fiber diameters. en_US
dc.type Article en_US
dc.relation.journal JOURNAL OF BIOMEDICAL OPTICS en_US
dc.identifier.issue 11 en_US
dc.identifier.volume 20 en_US
dc.contributor.authorID 0000-0002-4663-5410 : Tuba Denkçeken en_US
dc.contributor.authorID 0000-0003-3298-9725 : Murat Canpolat en_US
dc.identifier.wos 000366017500031 en_US
dc.identifier.doi 10.1117/1.JBO.20.11.115007 en_US
dc.contributor.sankoauthor Tuba Denkçeken en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Gazimuhtar Paşa Bulvarı
No:36
27090
Şehitkamil / GAZİANTEP