Factors Affecting Inadequate Empirical Antimicrobial Therapy and the Clinical Course of Upper Urinary Tract Infections in Elderly Patients: A Multicenter Study

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dc.contributor.author Korkmaz, Pınar
dc.contributor.author Kurtaran, Behice
dc.contributor.author Özdemir, Armagan
dc.contributor.author Turan Özden, Hale
dc.contributor.author Kaçar, Fatma
dc.contributor.author Ateş, Selma
dc.contributor.author Durmuş, Gül
dc.contributor.author Bayındır Bilman, Fulya
dc.contributor.author Uygun Kızmaz, Yeşim
dc.contributor.author Hamidi, Aziz Ahmad
dc.contributor.author Özdemir, Burcu
dc.contributor.author Burcu Yıkılgan, Aslıhan
dc.contributor.author Fırat, Pınar
dc.contributor.author İnan, Asuman
dc.contributor.author Okay, Gülay
dc.contributor.author Işık, Mehmet Emirhan
dc.contributor.author But, Ayşe
dc.contributor.author Ugurlu, Kenan
dc.contributor.author Harman, Rezan
dc.contributor.author Ergut Sezer, Büşra
dc.contributor.author Doyuk Kartal, Elif
dc.contributor.author Kuşçu, Ferit
dc.contributor.author Şener, Alper
dc.contributor.author Misatanoğlu Özatag, Duru
dc.contributor.author Tükenmez Tigen, Elif
dc.contributor.author Daglı, Özgür
dc.contributor.author Koçak, Funda
dc.contributor.author Kuşoğlu, Hülya
dc.contributor.author Ertürk Şengel, Buket
dc.contributor.author Demirel, Aslıhan
dc.contributor.author Naz, Hasan
dc.contributor.author Ağalar, Canan
dc.contributor.author Öztürk Engin, Derya
dc.contributor.author Dökmetaş, İlyas
dc.contributor.author Cancan Gürsul, Nur
dc.contributor.author Yılmaz Karadağ, Fatma
dc.contributor.author Çayıröz, Mehmet Umut
dc.contributor.author Kürekçi, Yeşim
dc.contributor.author Kadanali, Ayten
dc.contributor.author Cakar, Zeynep Şule
dc.contributor.author Savaşçı, Ümit
dc.contributor.author Erdem, İlknur
dc.contributor.author Çagan Aktaş, Sabahat
dc.date.accessioned 2021-10-15T13:13:31Z
dc.date.available 2021-10-15T13:13:31Z
dc.date.issued 2020
dc.identifier.issn 2147-673X
dc.identifier.uri http://openaccess.sanko.edu.tr/xmlui/handle/20.500.12527/434
dc.description.abstract Introduction: In this study, we aimed to determine the risk factors associated with inadequate empirical antibiotherapy (IEAT) and hospital-related mortality in elderly patients being treated for upper urinary tract infections (UTI). Materials and Methods: This study included individuals aged 65 years and over who were hospitalized after being diagnosed of community-acquired UTI or community-onset healthcare-associated UTI and followed-up in clinics and/or intensive care units (ICU) of 33 hospitals between March and September 2017. Results: A total of 525 patients (48% males; mean age: 76.46 +/- 7.93 years) were included in the study. Overall, 68.2% of the patients were hospitalized through the emergency department and 73.9% of patients were followed-up for pyelonephritis. Gram-negative, Gram-positive, and Gram-negative and positive mix growths were determined in 88%, 9.3%, and 2.7% of urine cultures, respectively. Fifty-six (10.7%) of the patients died. In multivariate analysis, the presence of chronic obstructive pulmonary disease [Odds ratio (OR): 2.278], age 85 years and over (OR: 2.816), admission to the ICU (OR: 14.831), and IEAT (OR: 2.364) were independent factors that significantly affected mortality. The presence of a urinary catheter, being followed-up in the ICU, benign prostate hypertrophy, use of antibiotics other than piperacillin-tazobactam and carbapenem were determined as independent factors that significantly affected IEAT (p<0.05). Conclusion: In our study, we found a direct correlation between IEAT and mortality. Therefore, knowing the most frequent microorganisms and antibiotic susceptibility profiles observed in the UTI of elderly patients may help to decrease the mortality and morbidity associated with these infections. en_US
dc.language.iso English en_US
dc.publisher GALENOS YAYINCILIKMOLLA GURANI MAHALLESI KACAMAK SOKAK NO 21, FINDIKZADE, ISTANBUL 34093, TURKEY en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject mortality en_US
dc.subject antibiotherapy en_US
dc.subject empirical en_US
dc.subject Urinary tract infection en_US
dc.title Factors Affecting Inadequate Empirical Antimicrobial Therapy and the Clinical Course of Upper Urinary Tract Infections in Elderly Patients: A Multicenter Study en_US
dc.type Article;Proceedings Paper en_US
dc.relation.journal MEDITERRANEAN JOURNAL OF INFECTION MICROBES AND ANTIMICROBIALS en_US
dc.identifier.volume 9 en_US
dc.contributor.authorID 0000-0002-1008-9681 : Kenan Ugurlu en_US
dc.contributor.authorID 0000-0002-0699-8890 : Mehmet Emirhan Işık en_US
dc.contributor.authorID 0000-0003-1616-2162 : Gülay Okay en_US
dc.identifier.wos 000591513500005 en_US
dc.identifier.doi 10.4274/mjima.galenos.2020.2020.5 en_US
dc.contributor.sankoauthor Rezan Harman en_US


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Gazimuhtar Paşa Bulvarı
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27090
Şehitkamil / GAZİANTEP