Protective Effect of Lycopene against Reperfusion Injury in Rats with Ovarian Torsion: A Biochemical and Histopathological Evaluation.

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dc.contributor.author Yilmaz, Emsal Pinar Topdagi
dc.contributor.author Un, Harun
dc.contributor.author Gundogdu, Betul
dc.contributor.author Polat, Elif
dc.contributor.author Askin, Seda
dc.contributor.author Topdagi, Yunus Emre
dc.contributor.author Halici, Zekai
dc.date.accessioned 2021-10-16T07:59:00Z
dc.date.available 2021-10-16T07:59:00Z
dc.date.issued 2020-03-01
dc.identifier.issn 0974-2727
dc.identifier.other 32792791
dc.identifier.uri http://openaccess.sanko.edu.tr/xmlui/handle/20.500.12527/437
dc.description.abstract  The aim of our study was to evaluate the effect of two different doses of lycopene, an antioxidant, on experimentally induced ovarian ischemia/reperfusion (IR) injury in rat model.  Twenty-four female rats were randomly divided into four groups: sham operation (group 1), 3-hour ischemia, 3-hour reperfusion (IR) (group 2), and IR + 100 mg/kg lycopene (PO) (group 3), IR + 200 mg/kg of lycopene (group 4). The rats' superoxide dismutase (SOD), myeloperoxidase (MPO) activities, malondialdehyde (MDA), and glutathione (GSH) levels were calculated. Ovarian tissue damage was assessed using a histopathological scoring system.  Serum parameter levels and histological scores showed that treatment with lycopene may be conservative approach to prevent IR injury after the ovarian detorsion procedure.The improvement with lycopene was higher at 200 mg than at 100 mg. The MPO and MDA values were significantly lower in groups 3 and 4 as compared with group 2 ( < 0.05), whereas the MPO and MDA values were lower in group 4 as compared with group 3.The SOD and GSH values were significantly higher in groups 3 and 4 as compared with group 2 ( < 0.05), whereas the SOD and GSH values were higher in group 4 as compared with group 3.Tissue damage scores were elevated in the IR group compared with the sham group, but the treatment with different lycopene doses after reperfusion improved the histopathological tissue damage scores.  The results showed that lycopene treatment reduced ovarian IR damage. Antioxidant activity was found to increase in a dose-dependent manner. Lycopene treatment may be conservative approach for ovarian torsion patients after the detorsion procedure to prevent IR damage. en_US
dc.language.iso English en_US
dc.publisher THIEME MEDICAL PUBL INC333 SEVENTH AVE, NEW YORK, NY 10001 USA en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject ischemia/reperfusion en_US
dc.subject lycopene en_US
dc.subject ovarian torsion en_US
dc.subject oxidative stress en_US
dc.title Protective Effect of Lycopene against Reperfusion Injury in Rats with Ovarian Torsion: A Biochemical and Histopathological Evaluation. en_US
dc.type Article en_US
dc.relation.journal JOURNAL OF LABORATORY PHYSICIANS en_US
dc.identifier.issue 1 en_US
dc.identifier.startpage 32 en_US
dc.identifier.endpage 37 en_US
dc.identifier.volume 12 en_US
dc.contributor.authorID 0000-0001-8593-5726 : Emsal Pınar Topdagı Yılmaz en_US
dc.contributor.authorID 0000-0003-0656-0765 : Yunus Emre Topdagı en_US
dc.identifier.wos 000559727800007 en_US
dc.identifier.doi 10.1055/s-0040-1715553 en_US
dc.contributor.sankoauthor Yunus Emre Topdağı en_US


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Gazimuhtar Paşa Bulvarı
No:36
27090
Şehitkamil / GAZİANTEP