dc.contributor.author | Erkutlu, Ibrahim | |
dc.contributor.author | Alptekin, Mehmet | |
dc.contributor.author | Geyik, Sirma | |
dc.contributor.author | Geyik, Abidin Murat | |
dc.contributor.author | Gezgin, Inan | |
dc.contributor.author | Gök, Abdulvahap | |
dc.date.accessioned | 2021-06-10T11:37:55Z | |
dc.date.available | 2021-06-10T11:37:55Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1673-5374 | |
dc.identifier.other | 25883626 | |
dc.identifier.uri | https://doi.org/10.4103/1673-5374.152381 | en_US |
dc.identifier.uri | http://openaccess.sanko.edu.tr/xmlui/handle/20.500.12527/202 | |
dc.description.abstract | Injury to peripheral nerves during injections of therapeutic agents such as penicillin G potassium is common in developing countries. It has been shown that cyclosporin A, a powerful immunosuppressive agent, can retard Wallerian degeneration after peripheral nerve crush injury. However, few studies are reported on the effects of cyclosporin A on peripheral nerve drug injection injury. This study aimed to assess the time-dependent efficacy of cyclosporine-A as an immunosuppressant therapy in an experimental rat nerve injection injury model established by penicillin G potassium injection. The rats were randomly divided into three groups based on the length of time after nerve injury induced by cyclosporine-A administration (30 minutes, 8 or 24 hours). The compound muscle action potentials were recorded pre-injury, early post-injury (within 1 hour) and 4 weeks after injury and compared statistically. Tissue samples were taken from each animal for histological analysis. Compared to the control group, a significant improvement of the compound muscle action potential amplitude value was observed only when cyclosporine-A was administered within 30 minutes of the injection injury (P < 0.05); at 8 or 24 hours after cyclosporine-A administration, compound muscle action potential amplitude was not changed compared with the control group. Thus, early immunosuppressant drug therapy may be a good alternative neuroprotective therapy option in experimental nerve injection injury induced by penicillin G potassium injection. | en_US |
dc.language.iso | English | en_US |
dc.publisher | WOLTERS KLUWER MEDKNOW PUBLICATIONS, WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S NO 1498A-2 VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Wallerian degeneration | en_US |
dc.subject | cyclosporine A | en_US |
dc.subject | injection injury | en_US |
dc.subject | nerve regeneration | en_US |
dc.subject | neural regeneration | en_US |
dc.subject | neuroelectrophysiology | en_US |
dc.subject | penicillin G potassium | en_US |
dc.subject | peripheral nerve injury | en_US |
dc.title | Early cyclosporin A treatment retards axonal degeneration in an experimental peripheral nerve injection injury model. | en_US |
dc.type | Article | en_US |
dc.relation.journal | NEURAL REGENERATION RESEARCH | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 266 | en_US |
dc.identifier.endpage | 270 | en_US |
dc.identifier.volume | 10 | en_US |
dc.contributor.authorID | 0000-0003-2166-9144 : Abidin Murat Geyik | en_US |
dc.contributor.authorID | 0000-0002-6665-7270 : Mehmet Alptekin | en_US |
dc.contributor.authorID | 0000-0002-5749-1504 : Ibrahim Erkutlu | en_US |
dc.identifier.wos | 000351783300023 | en_US |
dc.identifier.doi | 10.4103/1673-5374.152381 | en_US |
dc.contributor.sankoauthor | Abidin Murat Geyik | en_US |
Gazimuhtar Paşa Bulvarı
No:36
27090
Şehitkamil / GAZİANTEP