dc.contributor.author | Aydin, Cigdem | |
dc.contributor.author | Çetin, Zafer | |
dc.contributor.author | Manguoglu, Ayse Esra | |
dc.contributor.author | Tayfun, Funda | |
dc.contributor.author | Clark, Ozden Altiok | |
dc.contributor.author | Kupesiz, Alphan | |
dc.contributor.author | Akkaya, Bahar | |
dc.contributor.author | Karaüzüm, Sibel Berker | |
dc.date.accessioned | 2021-06-25T08:46:37Z | |
dc.date.available | 2021-06-25T08:46:37Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0971-4502 | |
dc.identifier.other | 27065576 | |
dc.identifier.uri | https://doi.org/ 10.1007/s12288-015-0557-7 | en_US |
dc.identifier.uri | http://openaccess.sanko.edu.tr/xmlui/handle/20.500.12527/275 | |
dc.description.abstract | Childhood acute lymphoblastic leukemia (ALL) is the most common type of childhood leukemia. Specifically, ALL is a malignant disorder of the lymphoid progenitor cells, with a peak incidence among children aged 2-5 years. The t(12;21)(p13;q22) translocation occurs in 25 % of childhood B cell precursor ALL. In this study, bone marrow samples were obtained from 165 patients with childhood ALL. We analyzed the t(12;21) translocation and other related abnormalities using the fluorescent in situ hybridization (FISH) technique with the ETV6(TEL)/RUNX1(AML1) ES dual color translocation probe. Conventional cytogenetic analyses were also performed. ETV6 and RUNX1 related chromosomal abnormalities were found in 42 (25.5 %) of the 165 patients with childhood ALL. Among these 42 patients, structural changes were detected in 33 (78.6 %) and numerical abnormalities in 9 (21.4 %). The frequency of FISH abnormalities in pediatric ALL cases were as follows: 8.5 % for t(12;21)(p13;q22) ETV6/RUNX1 fusion, 6.0 % for RUNX1 amplification, 3.0 % for tetrasomy/trisomy 21, 1.8 % for ETV6 deletion, 1.21 % for ETV6 deletion with RUNX1 amplification, 1.21 % for ETV6 amplification with RUNX1 amplification, 0.6 % for polyploidy, 0.6 % for RUNX1 deletion, and 0.6 % for diminished ETV6 signal. The most common structural abnormality was the t(12;21) translocation, followed by RUNX1 amplification and ETV6 deletion, while the most commonly observed numerical abnormality was trisomy 21. | en_US |
dc.language.iso | English | en_US |
dc.publisher | SPRINGER INDIA, 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001, INDIA | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Acute lymphoblastic leukemia | en_US |
dc.subject | ETV6 | en_US |
dc.subject | FISH | en_US |
dc.subject | RUNX1 | en_US |
dc.subject | t(12;21) translocation | en_US |
dc.title | Evaluation of ETV6/RUNX1 Fusion and Additional Abnormalities Involving ETV6 and/or RUNX1 Genes Using FISH Technique in Patients with Childhood Acute Lymphoblastic Leukemia. | en_US |
dc.type | Article | en_US |
dc.relation.journal | INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 154 | en_US |
dc.identifier.endpage | 161 | en_US |
dc.identifier.volume | 32 | en_US |
dc.contributor.authorID | 0000-0003-0125-235X : Zafer Çetin | en_US |
dc.identifier.wos | 000372248600005 | en_US |
dc.identifier.doi | 10.1007/s12288-015-0557-7 | en_US |
dc.contributor.sankoauthor | Zafer Çetin | en_US |
Gazimuhtar Paşa Bulvarı
No:36
27090
Şehitkamil / GAZİANTEP