dc.contributor.author | Eksi, Fahriye | |
dc.contributor.author | Pehlivan, Sacide | |
dc.contributor.author | Erdoğan, Mustafa Bilge | |
dc.contributor.author | Bayram, Aysen | |
dc.contributor.author | Balci, Sibel Oguzkan | |
dc.contributor.author | Yamak, Birol | |
dc.contributor.author | Pehlivan, Mustafa | |
dc.date.accessioned | 2021-07-02T13:43:21Z | |
dc.date.available | 2021-07-02T13:43:21Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1310-2818 | |
dc.identifier.uri | https://doi.org/ 10.1080/13102818.2017.1375864 | en_US |
dc.identifier.uri | http://openaccess.sanko.edu.tr/xmlui/handle/20.500.12527/330 | |
dc.description.abstract | The basic underlying factor for cardiovascular diseases is atherosclerosis, which is a multifactorial disease driven by environmental and genetic factors. We aimed to study the genetic polymorphism in mannose binding lectin-2 (MBL2) and macrophage migration inhibitory factor (MIF) in the arteries of patients with atherosclerotic lesions who underwent cardiac valve replacement for cardiac valve stenosis. Thirty-five patients (38.9%) operated with coronary bypass surgery (coronary group, CG), 55 (61.1%) patients operated with aortic or mitral valve replacement (valve group, VG) and 100 healthy controls were analyzed for codon 54 A/B polymorphism in the MBL2 gene and -173G/C polymorphism in the MIF gene by using the method of polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). The comparison of the healthy control group with CG and VG in terms of the MBL2 genotypes revealed significantly lower AA genotype and A allele ratios. The comparison of the healthy control group with CG and VG in terms of the MIF genotypes showed significantly lower GG genotype and G allele ratios. We suggest that the lower frequency of the GG genotype/G allele of the MIF gene and of the AA genotype/A allele of the MBL2 gene may be associated with the ethiopathogenesis of CG and VG patients. | en_US |
dc.publisher | TAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Coronary bypass surgery | en_US |
dc.subject | valve replacement | en_US |
dc.subject | mannose binding lectin-2 | en_US |
dc.subject | migration inhibitory factor | en_US |
dc.subject | gene polymorphisms | en_US |
dc.title | MBL2 and MIF gene polymorphisms in cardiovascular patients with atherosclerotic lesions undergoing heart valve replacement | en_US |
dc.type | Article | en_US |
dc.relation.journal | BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.startpage | 1173 | en_US |
dc.identifier.endpage | 1177 | en_US |
dc.identifier.volume | 31 | en_US |
dc.contributor.authorID | 0000-0003-0537-3028 : Sibel Oguzkan Balci | en_US |
dc.identifier.wos | 000414224000012 | en_US |
dc.identifier.doi | 10.1080/13102818.2017.1375864 | en_US |
dc.contributor.sankoauthor | Aysen Bayram | en_US |
Gazimuhtar Paşa Bulvarı
No:36
27090
Şehitkamil / GAZİANTEP