dc.contributor.author | Ozer, Gokhan | |
dc.date.accessioned | 2021-08-04T12:28:09Z | |
dc.date.available | 2021-08-04T12:28:09Z | |
dc.date.issued | 2018 | |
dc.identifier.other | 2587-196X | |
dc.identifier.uri | https://doi.org/ 10.14744/ejmo.2017.53824 | en_US |
dc.identifier.uri | http://openaccess.sanko.edu.tr/xmlui/handle/20.500.12527/367 | |
dc.description.abstract | Objectives: The aim of this study was to investigate the impact of L-Arginine on speech and language development in pediatric patients with hypoxic-ischemic encephalopathy (HIE). Methods: The oral language skills of 24 pediatric patients with HIE using L-Arginine were classified and the impact of L-Arginine on language skills was evaluated retrospectively. While there is no standard dose of L-Arginine, the usual dosage is 2.5 g orally for children younger than 5 years of age and 5 g orally for children older than 5 years of age. Results: The study enrolled 24 pediatric patients with a mean age of 3.9 years (range: 1.25-12 years). A pre-treatment median rating of 1 for oral language development increased to 3 post treatment, according to the results of a Wilcoxon signed-rank test used to examine the statistical significance of the difference between 2 variables. The difference was statistically significant. Conclusion: Although the exact pathophysiology of HIE has not been fully elucidated, it is associated with diffuse cerebral damage that leads to impaired motor and language development; moreover, HIE has no cure. In this study, L-Arginine therapy had a positive and significant impact on language development in children affected by HIE. Additional, larger series are needed to confirm these preliminary findings. | en_US |
dc.language.iso | English | en_US |
dc.publisher | KARE PUBLCONCORD ISTANBUL, DUMLUPINAR MAH, CIHAN SK NO 15, B BLOK 162 KADIKOY, ISTANBUL, TURKEY | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Hypoxic-ischemic encephalopathy | en_US |
dc.subject | language skills | en_US |
dc.subject | L-Arginine | en_US |
dc.title | Impact of L-Arginine on Language Skills in Children with Hypoxic-ischemic Encephalopathy | en_US |
dc.type | Article | en_US |
dc.relation.journal | EURASIAN JOURNAL OF MEDICINE AND ONCOLOGY | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 70 | en_US |
dc.identifier.endpage | 72 | en_US |
dc.identifier.volume | 2 | en_US |
dc.identifier.wos | 000604240400004 | en_US |
dc.identifier.doi | 10.14744/ejmo.2017.53824 | en_US |
dc.contributor.sankoauthor | Gökhan Özer | en_US |
Gazimuhtar Paşa Bulvarı
No:36
27090
Şehitkamil / GAZİANTEP