dc.contributor.author | Aydin, Begum | |
dc.contributor.author | Guvenc, Gokcen | |
dc.contributor.author | Altinbas, Burcin | |
dc.contributor.author | Niaz, Nasir | |
dc.contributor.author | Yalcin, Murat | |
dc.date.accessioned | 2021-08-10T12:35:08Z | |
dc.date.available | 2021-08-10T12:35:08Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0143-4179 | |
dc.identifier.other | 29751997 | |
dc.identifier.uri | https://doi.org/ 10.1016/j.npep.2018.05.001 | en_US |
dc.identifier.uri | http://openaccess.sanko.edu.tr/xmlui/handle/20.500.12527/380 | |
dc.description.abstract | Nesfatin-1, a peptide whose receptor is yet to be identified, has been shown to be involved in the modulation of feeding, stress, and metabolic responses. Recently, increasing evidence has supported a modulatory role of nesfatin-1 in cardiovascular activity. We have previously reported that nesfatin-1 causes an increase in blood pressure in normotensive and hypotensive rats by increasing plasma catecholamine, vasopressin, and renin levels. Recent reports suggest that nesfatin-1 may activate the central cholinergic system. However, there is no evidence showing an interaction between central nesfatin-1 and the cholinergic system. Therefore, this study aimed to determine whether the central cholinergic system may have a functional role in the nesfatin-1-induced cardiovascular effect observed in normotensive rats. Intracerebroventricular injection of nesfatin-1 caused short-term increases in mean arterial pressure and heart rate responses including bradycardic/tachycardic phases in normotensive animals. Central injection of nesfatin-1 increased the acetylcholine and choline levels in the posterior hypothalamus, as shown in microdialysis studies. Central pretreatment with the cholinergic muscarinic receptor antagonist atropine and/or nicotinic receptor antagonist mecamylamine blocked nesfatin-1-induced cardiovascular effects. In conclusion, the results show that centrally administered nesfatin-1 produces a pressor effect on blood pressure and heart rate responses including bradycardic/tachycardic phases in normotensive rats. Moreover, according to our findings, the central cholinergic system can modulate nesfatin-1-evoked cardiovascular activity. | en_US |
dc.language.iso | English | en_US |
dc.publisher | CHURCHILL LIVINGSTONEJOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Blood pressure | en_US |
dc.subject | Cholinergic muscarinic and nicotinic receptors | en_US |
dc.subject | Heart rate | en_US |
dc.subject | Nesfatin-1 | en_US |
dc.subject | Posterior hypothalamic choline/acetylcholine | en_US |
dc.title | Modulation of nesfatin-1-induced cardiovascular effects by the central cholinergic system. | en_US |
dc.type | Article | en_US |
dc.relation.journal | NEUROPEPTIDES | en_US |
dc.identifier.startpage | 9 | en_US |
dc.identifier.endpage | 15 | en_US |
dc.identifier.volume | 70 | en_US |
dc.contributor.authorID | 0000-0002-5600-8162 : Murat Yalcin | en_US |
dc.identifier.wos | 000440957400002 | en_US |
dc.identifier.doi | 10.1016/j.npep.2018.05.001 | en_US |
dc.contributor.sankoauthor | Burçin Altınbaş | en_US |
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Gazimuhtar Paşa Bulvarı
No:36
27090
Şehitkamil / GAZİANTEP