dc.contributor.author | Guvenc, Gokcen | |
dc.contributor.author | Altinbas, Burcin | |
dc.contributor.author | Kasikci, Esra | |
dc.contributor.author | Ozyurt, Ebru | |
dc.contributor.author | Bas, Aysenur | |
dc.contributor.author | Udum, Duygu | |
dc.contributor.author | Niaz, Nasir | |
dc.contributor.author | Yalcin, Murat | |
dc.date.accessioned | 2021-08-20T12:35:47Z | |
dc.date.available | 2021-08-20T12:35:47Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0303-4569 | |
dc.identifier.other | 31637758 | |
dc.identifier.uri | https://doi.org/ 10.1111/and.13410 | en_US |
dc.identifier.uri | http://openaccess.sanko.edu.tr/xmlui/handle/20.500.12527/415 | |
dc.description.abstract | Phoenixin (PNX) and nesfatin-1 are localised in the hypothalamus and the pituitary gland. Moreover, the most of the PNX-expressing neurons in the hypothalamus also co-express nesfatin-1. These outcomes may suggest that there is an interaction between PNX and nesfatin-1, at least in terms of neuroendocrine-mediated regulations. Hence, the study was planned to find out the effects of centrally delivered PNX and nesfatin-1 on male sex hormones or to show the interactive association of intracerebroventricularly (ICV) injected PNX+nesfatin-1 combination on the release of male hormones. PNX and nesfatin-1, single or together, were delivered ICV to different male Wistar Albino rat groups. Both PNX and nesfatin-1 induced a significant enhancement in plasma FSH, LH and testosterone without inducing any alteration in plasma GnRH in the rats. The central combinatorial treatment of both the neuropeptides produced a more potent rise in male plasma hormone levels than treating with single neuropeptide. In summary, our preliminary data show that centrally delivered PNX and nesfatin-1 can affect plasma male hormone levels. Moreover, that the combinatorial treatment with both the neuropeptides in male rats leading to a more potent effect on the plasma male hormone levels might suggest that both these neuropeptides act synergistically in terms of regulation of male HPGA. | en_US |
dc.publisher | WILEY111 RIVER ST, HOBOKEN 07030-5774, NJ | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | hypothalamic-pituitary-gonadal axis | en_US |
dc.subject | intracerebroventricular | en_US |
dc.subject | male sex hormones | en_US |
dc.subject | nesfatin-1 | en_US |
dc.subject | phoenixin | en_US |
dc.title | Contingent role of phoenixin and nesfatin-1 on secretions of the male reproductive hormones. | en_US |
dc.type | Article | en_US |
dc.relation.journal | ANDROLOGIA | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.volume | 51 | en_US |
dc.contributor.authorID | 0000-0002-5600-8162 : Murat Yalcin | en_US |
dc.contributor.authorID | 0000-0001-7052-1694 : Duygu Udum | en_US |
dc.contributor.authorID | 0000-0003-1591-510X : Ebru Ozyurt | en_US |
dc.contributor.authorID | 0000-0002-9534-736X : Burcin Altinbas | en_US |
dc.contributor.authorID | 0000-0002-1413-3651 : Gokcen Guvenc Bayram | en_US |
dc.identifier.wos | 000491929400001 | en_US |
dc.identifier.doi | 10.1111/and.13410 | en_US |
dc.contributor.sankoauthor | Burçin Altınbaş | en_US |
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |
Gazimuhtar Paşa Bulvarı
No:36
27090
Şehitkamil / GAZİANTEP