Factors Affecting Adverse Effects after Kidney Transplantation

Abstract

Objective: The incidence of developing adverse effects in recipients after kidney transplantation (Tx) was analyzed.Methods: A total of 206 patients (mean age was 41.40±11.88 years, 92.7% were between 46 and 59 years old, and 66.0% were men) whounderwent Tx between 2011 and 2016 were evaluated retrospectively. Information regarding the sociodemographic characteristics ofthe patients was collected using the “Sociodemographic Characteristics Data Collection Form,” which was created by the researcher.Results: Various adverse effects were detected in 206 patients who participated in our study. The incidence of adverse effects wassignificantly higher in patients who had hypertension and chronic glomerulonephritis who underwent dialysis treatment during0–12 months before Tx and who received a kidney transplant from a living donor (p=0.001). The incidence of adverse effects relatedto the immunosuppressive drugs used after transplantation was significantly higher in patients receiving mycophenolate mofetil(MMF)+steroid+tacrolimus and MMF+steroid+cyclosporine, and weight gain was higher in patients receiving the same group of drugs(p=0.001). There were no significant differences in terms of adverse effects that occurred in other drug combinations.Conclusion: We found that many factors (e.g., immunosuppressive drugs) in Tx patients may be associated with the incidence of adverseeffects.