Myricetin Decreases Ovarian and Lung Tissue Injury Induced by Ovarian Torsion- Detorsion: A Biochemical Study

Abstract

Objective: This study was designed to examine the effects of myricetin (Myr) on ovarianand lung tissue in rats with induced torsion-detorsion (TD) of bilateral ovaries to determinethe potential to reduce oxidative damage.Methods: The study group comprised 32 female Wistar albino rats randomly allocated to 4groups: sham, ovarian TD, Myr/25 (25 mg/kg dose of Myr+TD), and Myr/50 (50 mg/kg doseof Myr+TD).Results: The total oxidant status (TOS), malondialdehyde (MDA) level, oxidative stressindex (OSI), and myeloperoxidase (MPO) activity in both ovarian and lung tissues increasedsignificantly in the ovarian TD group compared with the sham group, while the superoxidedismutase (SOD) and total antioxidant status (TAS) values decreased in the same group. Incontrast, the SOD level increased, while MPO activity, the TOS, the OSI, and the MDA leveldecreased significantly in the Myr/25 and Myr/50 groups.Conclusion: Myr demonstrated protection against lung and ovarian tissue injury in induced-TD experimental rats.